Area of research
Oncology · Cancer Research
Research interest
Research interests include Cancer Genomics and Diagnostics, CRISPR and Genetic Engineering, Microtubule and mitosis dynamics, and PARP inhibition in cancer therapy.
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling
Acute expression of human APOBEC3B in mice results in RNA editing and lethality
Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing
Acute expression of human APOBEC3B in mice causes lethality associated with RNA editing
Aneuploid senescent cells activate NF-κB to promote their immune clearance by NK cells
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division
Author Correction: Cas9 activates the p53 pathway and selects for p53-inactivating mutations
Context is everything: aneuploidy in cancer
Genetic and transcriptional evolution alters cancer cell line drug response
Genomic evolution of cancer models: perils and opportunities
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells
Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer
Patient-derived xenografts undergo mouse-specific tumor evolution
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
Landscape of Genomic Alterations in Pituitary Adenomas
The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects
Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells
Genome maintenance in pluripotent stem cells
Chemical ablation of tumor-initiating human pluripotent stem cells
Virtual Karyotyping Reveals Greater Chromosomal Stability in Neural Cells Derived by Transdifferentiation than Those from Stem Cells
Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II Alpha
Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors
Analyzing the genomic integrity of stem cells
Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen