Area of research
Virology · Cancer Research
Research interest
Research interests include HIV Research and Treatment, Cancer Genomics and Diagnostics, HIV/AIDS drug development and treatment, and CRISPR and Genetic Engineering.
HAMMER: hairpin-based APOBEC3A-mediated mRNA editing reporter
APOBEC3 mutagenesis drives therapy resistance in breast cancer
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
<i>Faecalibacterium prausnitzii</i> regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice
APOBEC affects tumor evolution and age at onset of lung cancer in smokers
Structural basis for varying drug resistance of SARS-CoV-2 M <sup>pro</sup> E166 variants
Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity
Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation
A Novel Fluorescence Polarization Binding Assay for the Main Protease (M <sup>pro</sup> ) of SARS-CoV-2
Identification of Epstein-Barr virus BORF2 sequences required for APOBEC3B relocalization
APOBEC3B protein expression associates with poor prognosis for breast cancer patients with ER-positive disease
Regulatory Interactions between APOBEC3B N- and C-Terminal Domains
Publisher Correction: APOBEC3 mutagenesis drives therapy resistance in breast cancer
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes
A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system
Redefining high risk multiple myeloma with an APOBEC/Inflammation-based classifier
A high-throughput cell-based screening method for Zika virus protease inhibitor discovery
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A