Area of research
Infectious Diseases · Computational Theory and Mathematics
Research interest
Research focused on Protease and Virology, with related work in Vesicular stomatitis virus, DNA, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Notable publications include 'Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors', 'SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376', and 'HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators'.
Structural basis for varying drug resistance of SARS-CoV-2 M <sup>pro</sup> E166 variants
A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system
SARS-CoV-2 Mpro inhibitor identification using a cellular gain-of-signal assay for high-throughput screening
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors
Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage
Cellular Assays for Dynamic Quantification of Deubiquitinase Activity and Inhibition
SARS-CoV-2 3CL <sup>pro</sup> mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376
Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M <sup>pro</sup> /3CL <sup>pro</sup> in Living Cells
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases
Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species
HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators
Natural APOBEC3C variants can elicit differential HIV-1 restriction activity