Area of research
Molecular Biology · Virology
Research interest
Research interests include CRISPR and Genetic Engineering, HIV Research and Treatment, DNA Repair Mechanisms, and DNA and Nucleic Acid Chemistry.
Structural basis for double-stranded DNA cytosine deamination by BaDTF3 and its application in mitochondrial genome editing.
Direct interaction between human DDX1 and SARS-CoV-2 nucleocapsid protein is regulated by phosphorylation.
The atomic structure of human dystrophin spectrin-like repeat 24.
Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation.
Structural basis for bat receptor recognition by SARS-CoV-2 and bat SARS2-like coronaviruses.
Discovery, Structural Characterization, and Preclinical Evaluation of Monoclonal Antibodies against Xylazine Poisoning
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.
Structural basis for varying drug resistance of SARS-CoV-2 M <sup>pro</sup> E166 variants
Discovery of Small-Molecule Orthopoxvirus Resolvase Inhibitors with Antiviral Activity.
Structural basis for varying drug resistance of SARS-CoV-2 M<sup>pro</sup> E166 variants.
A Novel Fluorescence Polarization Binding Assay for the Main Protease (M <sup>pro</sup> ) of SARS-CoV-2
Crystal structure of the folded domains of Xrs2 from Saccharomyces cerevisiae.
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes.
Regulatory Interactions between APOBEC3B N- and C-Terminal Domains.
Regulatory Interactions between APOBEC3B N- and C-Terminal Domains
A Novel Fluorescence Polarization Binding Assay for the Main Protease (M<sup>pro</sup>) of SARS-CoV‑2.
The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors.
Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree.
Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation.
Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA.
Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree.
Crystal structures of forty- and seventy-one-substitution variants of hydroxynitrile lyase from rubber tree
A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain
A compact stem-loop DNA aptamer targets a uracil-binding pocket in the SARS-CoV-2 nucleocapsid RNA-binding domain.
Structural basis for raccoon dog receptor recognition by SARS-CoV-2.
Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination.
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes
Identification and biophysical characterization of a novel domain-swapped camelid antibody specific for fentanyl.