Area of research
Molecular Biology · Geriatrics and Gerontology
Research interest
Research interests include DNA Repair Mechanisms, Sirtuins and Resveratrol in Medicine, Genomics and Chromatin Dynamics, and Adipose Tissue and Metabolism.
Type-I-interferon-responsive microglia shape cortical development and behavior
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression
Direct analysis of brain phenotypes via neural blastocyst complementation
DNA double-strand breaks as drivers of neural genomic change, function, and disease
Sirt4 is a mitochondrial regulator of metabolism and lifespan in <i>Drosophila melanogaster</i>
Neural blastocyst complementation enables mouse forebrain organogenesis
Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay
Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells
<i>IgH</i> class switching exploits a general property of two DNA breaks to be joined <i>in cis</i> over long chromosomal distances
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining
Essential Developmental, Genomic Stability, and Tumour Suppressor Functions of the Mouse Orthologue of hSSB1/NABP2
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)
Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair