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James J. Dowling

University of New Brunswick · CA
Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Muscle Physiology and Disorders, Cardiomyopathy and Myosin Studies, Neurogenetic and Muscular Disorders Research, and Cellular transport and secretion.
h-index
64
citations
14,276
works
392
NIH funding
primary concept
email

Recent publications

Delandistrogene Moxeparvovec Gene Therapy in Individuals With Duchenne Muscular Dystrophy: Evidence in Focus
Neurology 2025cited by 25position: lastdoi
Gene therapy for children with X-linked myotubular myopathy: a plain language summary of publication for the ASPIRO study
Therapeutic Advances in Rare Disease 2025cited by 0position: middledoi
Standardization of zebrafish drug testing parameters for muscle diseases
Disease Models & Mechanisms 2024cited by 22position: middledoi
Multicenter Consensus Approach to Evaluation of Neonatal Hypotonia in the Genomic Era: A Review
JAMA Neurology 2022cited by 38position: middledoi
Variants in <i>CLDN5</i> cause a syndrome characterized by seizures, microcephaly and brain calcifications
Brain 2022cited by 30position: middledoi
INCEPTUS Natural History, Run-in Study for Gene Replacement Clinical Trial in X-Linked Myotubular Myopathy
Journal of Neuromuscular Diseases 2022cited by 25position: firstdoi
First-line options for systemic juvenile idiopathic arthritis treatment: an observational study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans
Pediatric Rheumatology 2022cited by 22position: middledoi
Molecular and cellular basis of genetically inherited skeletal muscle disorders
Nature Reviews Molecular Cell Biology 2021cited by 105position: firstdoi
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Nature Communications 2021cited by 62position: middledoi
Re: “Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy” by Wilson and Flotte
Human Gene Therapy 2020cited by 86position: middledoi
GATAD2B-associatedneurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-relateddisorder
Genetics in Medicine 2020cited by 33position: middledoi
P.105INCEPTUS pre-phase 1, prospective, non-interventional, natural history run-in study to evaluate subjects aged 4 years and younger with X-linked myotubular myopathy (XLMTM)
Neuromuscular Disorders 2019cited by 1position: middledoi
Uniparental disomy unveils a novel recessive mutation in POMT2
Neuromuscular Disorders 2018cited by 24position: middledoi
CONGENITAL MYOPATHIES (CNM)
Neuromuscular Disorders 2018cited by 0position: middledoi
Improving genetic diagnosis in Mendelian disease with transcriptome sequencing
Science Translational Medicine 2017cited by 800position: middledoi
A study of the reactivity of S<sup>(VI)</sup>–F containing warheads with nucleophilic amino-acid side chains under physiological conditions
Organic & Biomolecular Chemistry 2017cited by 163position: middledoi
217th ENMC International Workshop: RYR1-related myopathies, Naarden, The Netherlands, 29–31 January 2016
Neuromuscular Disorders 2016cited by 45position: middledoi
Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy
Journal of Clinical Investigation 2014cited by 203position: middledoi
Approach to the diagnosis of congenital myopathies
Neuromuscular Disorders 2013cited by 322position: middledoi
Severe congenital <i>RYR1</i> -associated myopathy
Neurology 2013cited by 108position: middledoi
Neuromuscular junction abnormalities in DNM2-related centronuclear myopathy
Journal of Molecular Medicine 2013cited by 81position: lastdoi
Consensus Statement on Standard of Care for Congenital Myopathies
Journal of Child Neurology 2012cited by 190position: middledoi
Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy
Human Mutation 2012cited by 137position: middledoi
C.P.2 In silico analysis of recessive RYR1 mutations identifies novel potential disease mechanisms
Neuromuscular Disorders 2012cited by 0position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Perry B. Shieh · Veterans Affairs Canada4 papers (2013–2020)Carsten G. Bönnemann · National Institutes of Health3 papers (2013–2020)Laurent Servais · University of Oxford3 papers (2018–2025)Nigel F. Clarke · The University of Adelaide3 papers (2012–2013)Francesco Muntoni · Great Ormond Street Hospital3 papers (2018–2022)Kimberly Amburgey · Hospital for Sick Children2 papers (2012–2013)Victoria MacBean · Brunel University of London2 papers (2018–2019)Caroline A. Sewry · Great Ormond Street Hospital2 papers (2013–2016)Barbara K. Smith · University of Florida2 papers (2018–2019)Mojtaba Noursalehi · University of Louisville2 papers (2018–2019)Teresa Pitts · University of Florida2 papers (2018–2019)Francesco Zorzato · University of Ferrara2 papers (2012–2016) · 2 papers (2018–2019)C. Bönnemann · University of California Davis Medical Center2 papers (2013–2018) · 2 papers (2018–2019)N. Kuntz · Lurie Children's Hospital2 papers (2018–2019)Deborah A. Bilder · Huntsman (United States)2 papers (2018–2019)Tina Duong · Palo Alto University2 papers (2018–2019) · 2 papers (2018–2019)Michael W. Lawlor · Medical College of Wisconsin2 papers (2018–2019)