Area of research
Pediatrics, Perinatology and Child Health · Pulmonary and Respiratory Medicine
Research interest
Research interests include Fibrosis, Downregulation and upregulation, Inflammation, Autocrine signalling, Fibroblast, and Medicine.
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models
The Translational Landscape of the Human Heart
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis
IL-11 is a crucial determinant of cardiovascular fibrosis
Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain