Area of research
Molecular Biology · Organic Chemistry
Research interest
Research interests include Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Click Chemistry and Applications, and Cannabis and Cannabinoid Research.
Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma
Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1
Adhesion-mediated mechanosignaling forces mitohormesis
Mitohormesis reprogrammes macrophage metabolism to enforce tolerance
Oncogene-regulated release of extracellular vesicles
4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor
A Cellular Mechanism to Detect and Alleviate Reductive Stress
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance
Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target
Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity
MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer
Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors
The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagosome Induction and the Metabolic Transition of Activated T Cells
Argininosuccinate Synthase 1 is a Metabolic Regulator of Colorectal Cancer Pathogenicity
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response