James Ippolito

Area of research

Hematology · Nutrition and Dietetics

Research interest

Research topics from publications: Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis; A Prolonged Bout of Running Increases Hepcidin and Decreases Dietary Iron Absorption in Trained Female and Male Runners; Mild to Moderate Food Deprivation Increases Hepcidin and Results in Hypoferremia and Tissue Iron Sequestration in Mice; Plasma Hepcidin Increases with Prolonged Running in Male, but Not Female, Collegiate Distance Runners with Low Iron Stores; Oral Iron Supplementation Increases Severity of Salmonella Typhimurium Infection. Representative work: . Unabsorbed iron in the lower intestine modifies the gut microbiome and promotes a more severe enteropathy. These findings could suggest the need for alternative iron supplementation strategies in areas where enteric infection are common Hepcidin is a negative regulator of extracellular iron availability and dietary iron absorption. Previous studies have shown that hepcidin increases with prolonged endurance exercise, but not in those with low iron stores (serum ferritin 0.05 for all). The post-exercise hepcidin response occurs in male, but not female, collegiate distance runners with low iron stores. These findings indicate that declines in iron status in female distance runners are independent of exercise-induced hepcidin. Intramural funds to S.R.H

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