Area of research
Molecular Biology
Research interest
Research interests include Cancer-related gene regulation, Epigenetics and DNA Methylation, Ubiquitin and proteasome pathways, and RNA modifications and cancer.
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding
Crystal structure of <scp>SARS‐CoV</scp>‐2 nsp10–nsp16 in complex with small molecule inhibitors, <scp>SS148</scp> and <scp>WZ16</scp>
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Target 2035 – update on the quest for a probe for every protein
A chemical toolbox for the study of bromodomains and epigenetic signaling
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
A Strategy for Modulation of Enzymes in the Ubiquitin System
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors