Area of research
Molecular Biology · Spectroscopy
Research interest
Research interests include Cancer-related gene regulation, Epigenetics and DNA Methylation, Analytical Chemistry and Chromatography, and RNA modifications and cancer.
Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology.
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor
Clinical biomarkers for thyroid immune-related adverse events in patients with stage III and IV gastrointestinal tumors
Regional quantification of cardiac metabolism with hyperpolarized [1 - <sup>13</sup> C]-pyruvate MRI evaluated in an oral glucose challenge
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.
Photoredox-Enabled Chromium-Catalyzed Alkene Diacylations
Inactive and active state structures template selective tools for the human 5-HT5A receptor
Inactive and active state structures template selective tools for the human 5-HT<sub>5A</sub> receptor.
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Structure, function and pharmacology of human itch GPCRs
Structure, function and pharmacology of human itch GPCRs
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders
Methylation of dual-specificity phosphatase 4 controls cell differentiation
Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.
Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders.
Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.
Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)
Designing Functionally Selective Noncatechol Dopamine D<sub>1</sub> Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68).
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D<sub>1</sub> Receptor Agonists.