Area of research
Molecular Biology · Genetics
Research interest
Research interests include Peroxisome Proliferator-Activated Receptors, Estrogen and related hormone effects, Nuclear Receptors and Signaling, and Receptor Mechanisms and Signaling.
Go big and go home: A bulky extension makes promiscuous ligands settle down
CAR directs T cell adaptation to bile acids in the small intestine
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling
PGRMC2 is an intracellular haem chaperone critical for adipocyte function
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
Defining a conformational ensemble that directs activation of PPARγ
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space
Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Regulation of p53 Stability and Apoptosis by a ROR Agonist