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Joseph L. Witztum

Optimum Therapeutics (United States) · US
Area of research
Immunology · Surgery
Research interest
Research interests include Atherosclerosis and Cardiovascular Diseases, Lipoproteins and Cardiovascular Health, Antioxidant Activity and Oxidative Stress, and Diabetes, Cardiovascular Risks, and Lipoproteins.
h-index
157
citations
93,363
works
605
NIH funding
primary concept
Medicine
email

Recent publications

Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA
Atherosclerosis 2025cited by 12position: lastdoi
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome
Circulation 2025cited by 3position: contributordoi
Brief communication: Strong concordance of the North American Familial Chylomicronemia Syndrome Score with a positive genetic diagnosis in patients from the Balance study
Journal of Clinical Lipidology 2025cited by 3position: contributordoi
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome
Circulation 2025cited by 3position: middledoi
Oxidized phospholipids in cardiovascular disease.
2024cited by 83position: contributordoi
Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia
New England Journal of Medicine 2024cited by 77position: middledoi
Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice
Arteriosclerosis Thrombosis and Vascular Biology 2024cited by 13position: middledoi
Time-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice.
2024cited by 12position: contributordoi
Oxidized phospholipids in cardiovascular disease
Nature Reviews Cardiology 2023cited by 112position: lastdoi
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia
Journal of clinical lipidology 2023cited by 45position: middledoi
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia
Journal of Clinical Lipidology 2023cited by 44position: contributordoi
Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial
Journal of clinical lipidology 2023cited by 40position: firstdoi
Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial
Journal of Clinical Lipidology 2023cited by 38position: contributordoi
Apolipoprotein C3 induces inflammasome activation only in its delipidated form
Nature Immunology 2023cited by 22position: middledoi
High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction
Journal of Lipid Research 2023cited by 18position: contributordoi
High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction
Journal of Lipid Research 2023cited by 18position: middledoi
Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol
Journal of the American College of Cardiology 2022cited by 196position: middledoi
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study
Journal of clinical lipidology 2022cited by 68position: middledoi
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study
Journal of Clinical Lipidology 2022cited by 67position: contributordoi
Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia
Journal of clinical lipidology 2022cited by 47position: middledoi
Shared Mechanisms between Cardiovascular Disease and NAFLD
Seminars in Liver Disease 2022cited by 41position: middledoi
Development and validation of an isoform-independent monoclonal antibody–based ELISA for measurement of lipoprotein(a)
Journal of Lipid Research 2022cited by 37position: middledoi
The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
JCI Insight 2022cited by 24position: middledoi
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
Immunity 2021cited by 730position: middledoi
Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial
The Lancet Diabetes & Endocrinology 2021cited by 222position: middledoi
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk
European Heart Journal 2021cited by 200position: middledoi
Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements
Journal of Lipid Research 2021cited by 109position: middledoi
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
2021cited by 76position: contributordoi
Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen
Atherosclerosis 2021cited by 25position: contributordoi
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease
New England Journal of Medicine 2020cited by 978position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Sotirios Tsimikas · Vanderbilt University Medical Center58 papers (2012–2025)Veronica J. Alexander · Ionis Pharmaceuticals (United States)15 papers (2014–2024)Calvin Yeang · University of California San Diego14 papers (2015–2022) · 14 papers (2019–2025)Richard S. Geary · Ionis Pharmaceuticals (United States)13 papers (2014–2024)Xiaohong Yang · University of California San Diego12 papers (2013–2020)Shuting Xia · Hesco (United States)10 papers (2016–2023)Erik S.G. Stroes · Amsterdam University of Applied Sciences10 papers (2012–2024)Daniel Gaudet · Thrombolysis in Myocardial Infarction Study Group10 papers (2014–2025)Sotirios Tsimikas · Elsevier, Inc.10 papers (2019–2025)Ayelet Gonen · University of California San Diego9 papers (2013–2022)Steven G. Hughes · Electronic BioSciences (United States)8 papers (2014–2019)Ewa Karwatowska‐Prokopczuk · Ionis Pharmaceuticals (United States)8 papers (2018–2024)Louis O’Dea · Akebia Therapeutics (United States)8 papers (2018–2022)Brenda F. Baker · Ionis Pharmaceuticals (United States)7 papers (2014–2025)Marlys L. Koschinsky · Czech Academy of Sciences, Institute of Psychology7 papers (2012–2020)Christoph J. Binder · Federal Agency for Scientific Organizations7 papers (2013–2023)Nicholas J. Viney · Ionis Pharmaceuticals (United States)7 papers (2015–2020)Yury I. Miller · University of San Diego7 papers (2012–2018)Christopher K. Glass · University of California San Diego6 papers (2014–2022)