Area of research
Molecular Biology · Geriatrics and Gerontology
Research interest
Research interests include Epigenetics and DNA Methylation, RNA modifications and cancer, DNA Repair Mechanisms, and Sirtuins and Resveratrol in Medicine.
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair
A Dual Role for the Histone Methyltransferase PR-SET7/SETD8 and Histone H4 Lysine 20 Monomethylation in the Local Regulation of RNA Polymerase II Pausing