Area of research
Molecular Biology · Oncology
Research interest
Research interests include DNA Repair Mechanisms, RNA modifications and cancer, PARP inhibition in cancer therapy, and Glaucoma and retinal disorders.
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair
The second mutation of SYCE1 gene associated with autosomal recessive nonobstructive azoospermia