Area of research
Genetics · Molecular Biology
Research interest
Research interests include Genetic Associations and Epidemiology, Genetic Mapping and Diversity in Plants and Animals, Genetic and phenotypic traits in livestock, and Bioinformatics and Genomic Networks.
Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
Deciphering the impact of genomic variation on function
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Evolutionary constraint and innovation across hundreds of placental mammals
Integrating gene annotation with orthology inference at scale
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Three-dimensional genome rewiring in loci with human accelerated regions
Evolutionary constraint and innovation across hundreds of placental mammals
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Evolution of the ancestral mammalian karyotype and syntenic regions
SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets
Population-specific causal disease effect sizes in functionally important regions impacted by selection
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Functionally informed fine-mapping and polygenic localization of complex trait heritability
Methotrexate and rheumatoid arthritis associated interstitial lung disease
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank
Extreme Polygenicity of Complex Traits Is Explained by Negative Selection
Genes with High Network Connectivity Are Enriched for Disease Heritability
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
Leveraging Polygenic Functional Enrichment to Improve GWAS Power
Mixed-model association for biobank-scale datasets
<i>MUC5B</i> Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis