Area of research
Infectious Diseases · Epidemiology
Research interest
Research interests include SARS-CoV-2 and COVID-19 Research, COVID-19 Clinical Research Studies, Respiratory viral infections research, and Viral gastroenteritis research and epidemiology.
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease
Structure-guided discovery of a small molecule inhibitor of SARS-CoV-2 main protease with potent <i>in vitro</i> and <i>in vivo</i> antiviral activities
Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant
Bacillus Calmette-Guérin–induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice
Targeting papain-like protease for broad-spectrum coronavirus inhibition
Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant
Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
Animal models for COVID-19
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Identification of a Novel Betacoronavirus (Merbecovirus) in Amur Hedgehogs from China
Identification of a Novel Ichthyic Parvovirus in Marine Species in Hainan Island, China
Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Coronaviruses — drug discovery and therapeutic options
Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways
Anti–IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia
Clinical Characteristics, Laboratory Identification, and <i>In Vitro</i> Antifungal Susceptibility of Yarrowia (Candida) lipolytica Isolates Causing Fungemia: a Multicenter, Prospective Surveillance Study