Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Monoclonal and Polyclonal Antibodies Research, HIV Research and Treatment, Wnt/β-catenin signaling in development and cancer, and SARS-CoV-2 and COVID-19 Research.
Astrocyte morphogenesis requires self-recognition
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques
Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques
Structures of LRP2 reveal a molecular machine for endocytosis
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking
Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses
Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site
Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function
Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
Lipocalin-2 is an anorexigenic signal in primates
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior
Sensing Actin Dynamics through Adherens Junctions
VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature
Cadherin-11 dimerization multi-site kinetics: combined partial unfolding and strand-swapping
Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization
Visualization of clustered protocadherin neuronal self-recognition complexes
Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing
Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine
<i>Trans</i>-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells
TOPAZ: A Positive-Unlabeled Convolutional Neural Network CryoEM Particle Picker that can Pick Any Size and Shape Particle
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits
Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior