Area of research
Virology · Infectious Diseases
Research interest
Research interests include Biology, Integrase, Human immunodeficiency virus (HIV), Virology, Chromatin, and Allosteric regulation.
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells
HIV integrase compacts viral DNA into biphasic condensates
LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
A ubiquitous disordered protein interaction module orchestrates transcription elongation
Block-And-Lock Strategies to Cure HIV Infection
The chromatin landscape at the HIV-1 provirus integration site determines viral expression
Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration
Establishment of latent HIV-1 reservoirs: what do we really know?
Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
Preclinical Evaluation of a P2X7 Receptor–Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
An integrated multi-electrode-optrode array for in vitro optogenetics
FK506 reduces neuroinflammation and dopaminergic neurodegeneration in an α-synuclein-based rat model for Parkinson's disease
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
rAAV-CFTRΔR Rescues the Cystic Fibrosis Phenotype in Human Intestinal Organoids and Cystic Fibrosis Mice
Retroviral integration: Site matters
Evaluation of the expression pattern of rAAV2/1, 2/5, 2/7, 2/8, and 2/9 serotypes with different promoters in the mouse visual cortex
Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex
Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors
Host factors for retroviral integration site selection
LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)
BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements
HIV-1 Integrase Variants Retarget Viral Integration and Are Associated with Disease Progression in a Chronic Infection Cohort
Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy