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Thomas D. Arnold

University of California, San Francisco · US
Area of research
Neurology · Immunology
Research interest
Research interests include Neuroinflammation and Neurodegeneration Mechanisms, Immune cells in cancer, Barrier Structure and Function Studies, and Immune Response and Inflammation.
h-index
29
citations
4,451
works
64
NIH funding
primary concept
email

Recent publications

Dynamic fibroblast–immune interactions shape recovery after brain injury
Nature 2025cited by 26position: middledoi
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity
Nature Communications 2025cited by 15position: lastdoi
Type-I-interferon-responsive microglia shape cortical development and behavior
Cell 2024cited by 139position: middledoi
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
Neuron 2024cited by 43position: middledoi
A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models
Cell Reports 2024cited by 41position: middledoi
Structural and molecular basis of choline uptake into the brain by FLVCR2
Nature 2024cited by 40position: middledoi
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus
Cell Reports Medicine 2024cited by 6position: middledoi
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Nature Immunology 2023cited by 188position: middledoi
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research
Stem Cell Reports 2022cited by 84position: middledoi
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
Nature Neuroscience 2021cited by 202position: middledoi
Microglia are involved in the protection of memories formed during sleep deprivation
Neurobiology of Sleep and Circadian Rhythms 2021cited by 31position: middledoi
A new genetic strategy for targeting microglia in development and disease
eLife 2020cited by 176position: lastdoi
Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction
The Journal of Experimental Medicine 2019cited by 65position: firstdoi
Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature
Cell Reports 2017cited by 109position: middledoi
Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice
Journal of Cerebral Blood Flow & Metabolism 2017cited by 81position: middledoi
The α <sub>v</sub> β <sub>1</sub> integrin plays a critical in vivo role in tissue fibrosis
Science Translational Medicine 2015cited by 300position: middledoi
LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation
The Journal of Cell Biology 2015cited by 136position: middledoi
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
Development 2014cited by 102position: firstdoi
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Nature Medicine 2013cited by 866position: middledoi
Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGF-β–TAK1–Dependent Mechanism
PLoS Biology 2013cited by 54position: middledoi
Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin αVβ8-Mediated Activation of Transforming Growth Factor-β
Journal of Neuroscience 2012cited by 85position: firstdoi

Grants

RUI: EPIGENETIC WEAPONS IN PLANT-HERBIVORE INTERACTIONS: SULFORAPHANE AS A NATURAL HISTONE DEACETYLASE INHIBITOR IN LEPIDOPTERAN PESTS
NSF2151434$329,5562022–2026PIRePORTER
Development of an Interdisciplinary Course, Chemical Analysis in Chemical Ecology
NSF0942570$199,9032010–2014PIRePORTER
Collaborative Research: Competing Sinks as Constraints on Plant Defense Responses
NSF0614893$157,1872006–2010PIRePORTER
RUI Collaboraitve Research: Mechanisms of induced pathogen resistance in seagrasses
NSF0336716$66,6082003–2005PIRePORTER
Collaborative Research: Coordinate Induction of Sink Strength and Polyphenol Metabolism in Trees
NSF0336717$53,4062003–2005PIRePORTER
RUI Collaboraitve Research: Mechanisms of induced pathogen resistance in seagrasses
NSF0117313$103,8692001–2003PIRePORTER
Collaborative Research: Coordinate Induction of Sink Strength and Polyphenol Metabolism in Trees
NSF0114458$64,8692001–2003PIRePORTER
Water Resource Conference on Minimum Streamflow Issues For Massachusetts, April 1981, Boston, Massachusetts
NSF8016342$47,4031980–1982PIRePORTER

Frequent collaborators

Nicolás Santander · University of O'Higgins5 papers (2019–2025)Dean Sheppard · Pulmonary and Critical Care Associates5 papers (2013–2025)Gabriel L. McKinsey · University of California, San Francisco4 papers (2020–2025)Louis F. Reichardt · Technical University of Munich4 papers (2012–2019)Eric J. Huang · University of California, San Francisco4 papers (2012–2024)Carlos O. Lizama · University of California, San Francisco4 papers (2019–2025)Christer Betsholtz · Uppsala University3 papers (2013–2017)Yoh‐suke Mukouyama · National Heart Lung and Blood Institute3 papers (2014–2019)Richard Daneman · University of California San Diego3 papers (2015–2024)Elisabeth Raschperger · Karolinska Institutet2 papers (2013–2017)Kelly M. Cautivo · University of California, San Francisco2 papers (2019–2021)Aditya Katewa · University School2 papers (2024–2025)Konstantin Gaengel · Uppsala University2 papers (2014–2017)Dibyanti Mukherjee · University of California, San Francisco2 papers (2024–2025)B. Jung · Beth Israel Deaconess Medical Center2 papers (2014–2017)G. Ferrero · Consejo Nacional de Investigaciones Científicas y Técnicas2 papers (2012–2014)Rosemary J. Akhurst · University of California, San Francisco2 papers (2012–2014)Amara Larpthaveesarp · University of California, San Francisco2 papers (2020–2024)Satchal K. Erramilli · University of Chicago1 papers (2024–2024)Oliver B. Clarke · Durham University1 papers (2024–2024)