Area of research
Epidemiology · Hepatology
Research interest
Research interests include Hepatitis B Virus Studies, Liver Disease Diagnosis and Treatment, Liver physiology and pathology, and Hepatitis C virus research.
Pruritus in primary biliary cholangitis: insights from the German PBC registry across secondary and tertiary care
HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx
Sub-optimal therapy of patients with primary biliary cholangitis (PBC) in the real-life stetting of the German PBC cohort
Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20
Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane
Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control
Resistance‐associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
The immunology of hepatocellular carcinoma
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis
Single cell polarity in liquid phase facilitates tumour metastasis
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication
Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice
Transcriptome‐based profiling of yolk sac‐derived macrophages reveals a role for Irf8 in macrophage maturation
Canonical NF‐κB signaling in hepatocytes acts as a tumor‐suppressor in hepatitis B virus surface antigen‐driven hepatocellular carcinoma by controlling the unfolded protein response
Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
Lineage fate of ductular reactions in liver injury and carcinogenesis
Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes
Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells