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Kyle N. Klein

Allen Institute for Cell Science · US
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Area of research
Molecular Biology
Research interest
Research interests include Genomics and Chromatin Dynamics, DNA Repair Mechanisms, Epigenetics and DNA Methylation, and CRISPR and Genetic Engineering.
h-index
13
citations
948
works
35
NIH funding
primary concept
email

Recent publications

Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories
Cell Systems 2025cited by 3position: middledoi
Emergence of replication timing during early mammalian development
Nature 2023cited by 55position: middledoi
RIF1 regulates replication origin activity and early replication timing in B cells
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 3position: middledoi
Cohesin-mediated loop anchors confine the locations of human replication origins
Nature 2022cited by 127position: middledoi
Replication timing maintains the global epigenetic state in human cells
Science 2021cited by 168position: firstdoi
Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication
Molecular Cell 2021cited by 113position: middledoi
Nuclear organisation and replication timing are coupled through RIF1–PP1 interaction
Nature Communications 2021cited by 55position: middledoi
Catalytically Enhanced Cas9 Through Directed Protein Evolution
The CRISPR Journal 2021cited by 17position: middledoi
Cohesin-mediated loop anchors confine the location of human replication origins
bioRxiv (Cold Spring Harbor Laboratory) 2021cited by 11position: middledoi
Statistical Comparisons Of Chromosomal Shape Populations
2021cited by 1position: middledoi
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
Nature Communications 2020cited by 61position: middledoi
Genome-Wide Mapping of Human DNA Replication by Optical Replication Mapping Supports a Stochastic Model of Eukaryotic Replication
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 17position: middledoi
Catalytically Enhanced Cas9 through Directed Protein Evolution
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 3position: middledoi
Single‐Molecule Optical Replication Mapping (ORM) Suggests Human Replication Timing is Regulated by Stochastic Initiation
The FASEB Journal 2020cited by 0position: middledoi
Replication timing alterations in leukemia affect clinically relevant chromosome domains
Blood Advances 2019cited by 26position: middledoi
Replication timing maintains the global epigenetic state in human cells
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 12position: firstdoi
Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 8position: middledoi
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 7position: middledoi
Variable Retention of Differentiation-specific DNA Replication Timing in Human Pediatric Leukemia
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 1position: middledoi
Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication
Cell 2018cited by 199position: middledoi
Identification of <i>cis</i> Elements for Spatio-temporal Control of DNA Replication
SSRN Electronic Journal 2018cited by 1position: middledoi
Identification of <i>cis</i> elements for spatio-temporal control of DNA replication
bioRxiv (Cold Spring Harbor Laboratory) 2018cited by 0position: middledoi
Genome-Wide Identification of Early-Firing Human Replication Origins by Optical Replication Mapping
bioRxiv (Cold Spring Harbor Laboratory) 2017cited by 14position: firstdoi
Epigenetic vs. Sequence-Dependent Control of Eukaryotic Replication Timing
2016cited by 5position: firstdoi

Grants

No grants ingested yet.

Frequent collaborators

David M. Gilbert · Hebrew University of Jerusalem23 papers (2016–2023)Peiyao A Zhao · Allen Institute6 papers (2018–2022)Takayo Sasaki · Florida State University5 papers (2019–2022) · 5 papers (2017–2022)Claudia Trevilla‐García · University of Minnesota Medical Center5 papers (2018–2019)Daniel A. Bartlett · Florida State University5 papers (2018–2021)Juan Carlos Rivera‐Mulia · Jackson Laboratory5 papers (2018–2019)Hongbo Yang · Fudan University4 papers (2020–2022) · 4 papers (2017–2022)Nick Rhind · University of Massachusetts Chan Medical School4 papers (2017–2021)Andreas Maiser · Ludwig-Maximilians-Universität München4 papers (2019–2021)Alex Hastie · University of Washington4 papers (2017–2021)Peter Fraser · Cancer Research UK Cambridge Center3 papers (2018–2018)Mats Ljungman · University of Michigan–Ann Arbor3 papers (2018–2018)Abhijit Chakraborty · McGill University Health Centre3 papers (2018–2018)Tyler Borrman · University of Massachusetts Chan Medical School3 papers (2017–2021) · 3 papers (2020–2021)Vishnu Dileep · Massachusetts Institute of Technology3 papers (2018–2018)Katerina Kraft · Amgen (United States)3 papers (2018–2018)Elphège P. Nora · University of California, San Francisco3 papers (2018–2018)
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