Area of research
Geriatrics and Gerontology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Sirtuins and Resveratrol in Medicine, Adipose Tissue and Metabolism, Cardiomyopathy and Myosin Studies, and Cardiac Fibrosis and Remodeling.
The multifaceted role of sirtuins in inflammatory bowel diseases
Characterization and molecular targeting of CFIm25 (NUDT21/CPSF5) mRNA using miRNAs.
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
Is nuclear sirtuin SIRT6 a master regulator of immune function?
SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
Molecular regulation of mitochondrial dynamics in cardiac disease
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage
Role of Sirtuins in Regulating Pathophysiology of the Heart
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β
Regulation of Akt Signaling by Sirtuins
Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling
SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer
Posttranslational modification of Sirt6 activity by peroxynitrite
Deficiency of Cardiomyocyte-specific MicroRNA-378 Contributes to the Development of Cardiac Fibrosis Involving a Transforming Growth Factor β (TGFβ1)-dependent Paracrine Mechanism
SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
A Cardiac-enriched MicroRNA, miR-378, Blocks Cardiac Hypertrophy by Targeting Ras Signaling
Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
A Novel Cardiomyocyte-enriched MicroRNA, miR-378, Targets Insulin-like Growth Factor 1 Receptor
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro
SBIR Phase I: Die Optimization Software for Coextruded Multilayer Plastic Products
SBIR Phase I: Die Design Software for Polymer Coextrusion Including Layer Rearrangement Due to Viscous Encapsulation and Secondary Flow
SBIR Phase I: Optimization of Screw Geometry and Processing Conditions using Three-Dimensional Simulation of Melting and Melt Flow in Twin-Screw Extruders
SBIR Phase I: Three-Dimensional Simulation of Polymer Coextrusion using a Fixed Finite Element Mesh
SBIR Phase I: Software for Three-Dimensional Simulation of Polymer Coextrusion
GOALI: Optimum Design of Extrusion Dies using the Estimated Elongational Viscosity of Polymers
GOALI/IUCP: A Flow Simulation and Mold Design for Plastic Encapsulation of Microchips