Area of research
Geriatrics and Gerontology · Physiology
Research interest
Research interests include Sirtuins and Resveratrol in Medicine, Adipose Tissue and Metabolism, Mitochondrial Function and Pathology, and Autophagy in Disease and Therapy.
The multifaceted role of sirtuins in inflammatory bowel diseases
The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity‐mediated diabetic cardiomyopathy
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice
The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice
SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β
SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling