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Stephen L. Chan

California Pacific Medical Center · HK
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Area of research
Hepatology · Oncology
Research interest
Research interests include Hepatocellular Carcinoma Treatment and Prognosis, Cancer Immunotherapy and Biomarkers, Cholangiocarcinoma and Gallbladder Cancer Studies, and Pancreatic and Hepatic Oncology Research.
h-index
84
citations
35,614
works
717
NIH funding
primary concept
Medicine
email

Recent publications

Adjuvant pembrolizumab for participants with hepatocellular carcinoma and complete radiologic response after surgical resection or local ablation: The phase 3 keynote-937 study.
Journal of Clinical Oncology 2026cited by 5position: firstdoi
Safety outcomes with tremelimumab (T) rechallenge in the phase 3 HIMALAYA study of T plus durvalumab (D) in unresectable hepatocellular carcinoma.
Journal of Clinical Oncology 2026cited by 1position: middledoi
Durvalumab with or without bevacizumab with transarterial chemoembolisation in hepatocellular carcinoma (EMERALD-1): a multiregional, randomised, double-blind, placebo-controlled, phase 3 study
The Lancet 2025cited by 206position: middledoi
The Lancet Commission on addressing the global hepatocellular carcinoma burden: comprehensive strategies from prevention to treatment
The Lancet 2025cited by 104position: firstdoi
Five-year overall survival update from the HIMALAYA study of tremelimumab plus durvalumab in unresectable HCC
Journal of Hepatology 2025cited by 92position: middledoi
Multicenter Phase 2 Trial of Second-Line Regorafenib in Patients with Unresectable Hepatocellular Carcinoma after Progression on Atezolizumab plus Bevacizumab
Liver Cancer 2025cited by 12position: middledoi
Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): final analysis of a randomised, open-label, international, phase 3 study
The Lancet Oncology 2025cited by 8position: middledoi
A Prognostic Index for Advanced Biliary Tract Cancer Treated With Cisplatin, Gemcitabine and Durvalumab: The <scp>MAGIC</scp> ‐D Index
Liver International 2025cited by 6position: middledoi
Factors associated with reaching maintenance therapy in patients with advanced biliary tract cancer treated with durvalumab: Real‐world results from a multicenter and multinational study
International Journal of Cancer 2025cited by 2position: middledoi
The impact of molecular alterations in patients with advanced biliary tract cancer receiving cisplatin, gemcitabine, and durvalumab: a large, real-life, worldwide population
JNCI Journal of the National Cancer Institute 2025cited by 2position: middledoi
Negative impact of corticosteroid use on outcome in patients with advanced <scp>BTCs</scp> treated with cisplatin, gemcitabine, and durvalumab: A large real‐life worldwide population
International Journal of Cancer 2025cited by 1position: middledoi
Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab
European Journal of Cancer 2025cited by 0position: middledoi
Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma
Annals of Oncology 2024cited by 292position: middledoi
EMERALD-1: A phase 3, randomized, placebo-controlled study of transarterial chemoembolization combined with durvalumab with or without bevacizumab in participants with unresectable hepatocellular carcinoma eligible for embolization.
Journal of Clinical Oncology 2024cited by 150position: middledoi
APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024
Hepatology International 2024cited by 48position: middledoi
Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: A large real-life worldwide population
European Journal of Cancer 2024cited by 42position: middledoi
Outcomes in the Asian subgroup of the phase III randomised HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma
Journal of Hepatology 2024cited by 35position: lastdoi
Camrelizumab plus rivoceranib vs sorafenib as first-line therapy for unresectable hepatocellular carcinoma (uHCC): Final overall survival analysis of the phase 3 CARES-310 study.
Journal of Clinical Oncology 2024cited by 35position: middledoi
Three-year follow-up data from KEYNOTE-966: Pembrolizumab (pembro) plus gemcitabine and cisplatin (gem/cis) compared with gem/cis alone for patients (pts) with advanced biliary tract cancer (BTC).
Journal of Clinical Oncology 2024cited by 31position: middledoi
Efficacy of cisplatin-gemcitabine-durvalumab in patients with advanced biliary tract cancer experiencing early vs late disease relapse after surgery: a large real-life worldwide population
The Oncologist 2024cited by 7position: middledoi
Durvalumab Plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer: A Large Real-Life Worldwide Population
SSRN Electronic Journal 2024cited by 3position: middledoi
Impact of Antibiotic Therapy in Patients with Cholangiocarcinoma Treated with Chemoimmunotherapy
SSRN Electronic Journal 2024cited by 0position: middledoi
Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet 2023cited by 982position: middledoi
Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study
The Lancet 2023cited by 645position: middledoi
Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study
The Lancet Oncology 2023cited by 107position: middledoi
Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma: Longer Term Follow-Up from the Phase 3 KEYNOTE-240 Trial
Liver Cancer 2023cited by 44position: middledoi
Tebotelimab, a PD-1/LAG-3 bispecific antibody, in patients with advanced hepatocellular carcinoma who had failed prior targeted therapy and/or immunotherapy: An open-label, single-arm, phase 1/2 dose-escalation and expansion study.
Journal of Clinical Oncology 2023cited by 22position: lastdoi
SO-15 Four-year overall survival update from the phase 3 HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma
Annals of Oncology 2023cited by 21position: middledoi
Plain language summary of the HIMALAYA study: tremelimumab and durvalumab for unresectable hepatocellular carcinoma (liver cancer)
Future Oncology 2023cited by 16position: middledoi
Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma
NEJM Evidence 2022cited by 1,386position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ann‐Lii Cheng · Xi'an Jiaotong University13 papers (2018–2024)Masatoshi Kudo · Kindai University13 papers (2018–2024)Philippe Merle · Université Claude Bernard Lyon 110 papers (2018–2023)Robin Kate Kelley · UCSF Helen Diller Family Comprehensive Cancer Center10 papers (2018–2026)Bruno Sangro · KU Leuven9 papers (2016–2024)Richard S. Finn · United States Olympic & Paralympic Committee8 papers (2018–2025)Ghassan K. Abou‐Alfa · Verizon (United States)8 papers (2018–2024)Thomas Yau · Hôpital Pontchaillou8 papers (2019–2024)Lorenza Rimassa · European Organisation for Research and Treatment of Cancer7 papers (2018–2023)Peter R. Galle · University of Lübeck7 papers (2016–2023)Arndt Vogel · Federal Institute for Risk Assessment7 papers (2016–2022)Abby B. Siegel · Merck & Co., Inc., Rahway, NJ, USA (United States)7 papers (2018–2026) · 7 papers (2016–2021)В. В. Бредер · Russian Cancer Research Center NN Blokhin7 papers (2019–2026)Baek‐Yeol Ryoo · Ulsan College6 papers (2018–2025)Tim Meyer · University College London6 papers (2017–2020)Bruno Daniele · Federico II University Hospital6 papers (2018–2023)Jennifer J. Knox · Ontario Institute for Cancer Research6 papers (2018–2023)Julien Edeline · University of Genoa6 papers (2018–2024)Andrew X. Zhu · Weill Cornell Medicine6 papers (2018–2022)
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