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Kristen Hege

Independent Sector · US
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Area of research
Oncology · Immunology
Research interest
Research interests include CAR-T cell therapy research, Immunotherapy and Immune Responses, Cancer Immunotherapy and Biomarkers, and Multiple Myeloma Research and Treatments.
h-index
44
citations
11,849
works
163
NIH funding
primary concept
Medicine
email

Recent publications

Phase 1 clinical trial of B-Cell Maturation Antigen (BCMA) NEX-T® Chimeric Antigen Receptor (CAR) T cell therapy CC-98633/BMS-986354 in participants with triple-class exposed multiple myeloma
Leukemia 2025cited by 6position: middledoi
Going with the Flow: Circulating Tumor-Reactive Lymphocytes Stream into Cancer Therapy.
2025cited by 0position: contributordoi
S193: BMS-986393 (CC-95266), A G PROTEIN–COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D (GPRC5D)–TARGETED CAR T-CELL THERAPY FOR RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): RESULTS FROM A PHASE 1 STUDY
HemaSphere 2023cited by 15position: middledoi
Phase 1 study of anti-CD47 monoclonal antibody CC-90002 in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes
Annals of Hematology 2022cited by 91position: middledoi
Results from the First Phase 1 Clinical Study of the B-Cell Maturation Antigen (BCMA) Nex T Chimeric Antigen Receptor (CAR) T Cell Therapy CC-98633/BMS-986354 in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Blood 2022cited by 39position: middledoi
Clinical Activity of BMS-986393 (CC-95266), a G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D)-Targeted Chimeric Antigen Receptor (CAR) T Cell Therapy, in Patients with Relapsed and/or Refractory (R/R) Multiple Myeloma (MM): First Results from a Phase 1, Multicenter, Open-Label Study
Blood 2022cited by 39position: middledoi
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
New England Journal of Medicine 2021cited by 2,368position: middledoi
Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
Nature Communications 2021cited by 404position: middledoi
Idecabtagene vicleucel (ide-cel, bb2121), a BCMA-directed CAR T cell therapy, in relapsed and refractory multiple myeloma: Updated KarMMa results.
Journal of Clinical Oncology 2021cited by 66position: middledoi
Interim Results from the First Clinical Study of CC-95251, an Anti-Signal Regulatory Protein-Alpha (SIRPα) Antibody, in Combination with Rituximab in Patients with Relapsed and/or Refractory Non-Hodgkin Lymphoma (R/R NHL)
Blood 2021cited by 20position: middledoi
Idecabtagene vicleucel (ide-cel; bb2121), a BCMA-targeted CAR T-cell therapy, in patients with relapsed and refractory multiple myeloma (RRMM): Initial KarMMa results.
Journal of Clinical Oncology 2020cited by 121position: middledoi
Updated Results from the Phase I CRB-402 Study of Anti-Bcma CAR-T Cell Therapy bb21217 in Patients with Relapsed and Refractory Multiple Myeloma: Correlation of Expansion and Duration of Response with T Cell Phenotypes
Blood 2020cited by 85position: middledoi
Avadomide plus obinutuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (CC-122-NHL-001): a multicentre, dose escalation and expansion phase 1 study
The Lancet Haematology 2020cited by 33position: middledoi
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma
New England Journal of Medicine 2019cited by 1,721position: middledoi
First Clinical Study of the B-Cell Maturation Antigen (BCMA) 2+1 T Cell Engager (TCE) CC-93269 in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Interim Results of a Phase 1 Multicenter Trial
Blood 2019cited by 158position: middledoi
<p>First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy</p>
Cancer Management and Research 2019cited by 84position: middledoi
Updated Results from an Ongoing Phase 1 Clinical Study of bb21217 Anti-Bcma CAR T Cell Therapy
Blood 2019cited by 69position: middledoi
A Phase I Study of CC-90002, a Monoclonal Antibody Targeting CD47, in Patients with Relapsed and/or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS): Final Results
Blood 2019cited by 50position: middledoi
Anti-CD47 Antibody, CC-90002, in Combination with Rituximab in Subjects with Relapsed and/or Refractory Non-Hodgkin Lymphoma (R/R NHL)
Blood 2019cited by 35position: middledoi
Initial Results from a Phase 1 Clinical Study of bb21217, a Next-Generation Anti Bcma CAR T Therapy
Blood 2018cited by 89position: middledoi
bb2121 anti-BCMA CAR T-cell therapy in patients with relapsed/refractory multiple myeloma: Updated results from a multicenter phase I study.
Journal of Clinical Oncology 2018cited by 63position: middledoi
Early MRD negativity to predict deepening myeloma response in relapsed/refractory multiple myeloma (RRMM) patients treated with bb2121 anti-BCMA CAR T cells.
Journal of Clinical Oncology 2018cited by 10position: middledoi
Association of high baseline ferritin with tocilizumab administration for CRS in relapsed/refractory multiple myeloma patients treated with bb2121 anti-BCMA CAR T cells.
Journal of Clinical Oncology 2018cited by 0position: middledoi
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
Journal for ImmunoTherapy of Cancer 2017cited by 319position: firstdoi
A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanced solid tumors or multiple myeloma
Cancer 2015cited by 76position: middledoi
Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
Science Translational Medicine 2012cited by 645position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Jesús G. Berdeja · The Centers11 papers (2018–2023)Fabio Petrocca · Bristol-Myers Squibb (Sweden)10 papers (2018–2021)Noopur Raje · Harvard University9 papers (2018–2021)Michael R. Burgess · Bristol-Myers Squibb (United States)9 papers (2019–2025)David S. Siegel · Universidade Federal de Santa Catarina9 papers (2018–2021)Sundar Jagannath · All India Institute of Medical Sciences9 papers (2018–2021)Nikhil C. Munshi · Harvard University9 papers (2018–2021)Yi Lin · South China Agricultural University8 papers (2018–2021)Timothy Campbell · Bristol-Myers Squibb (Sweden)8 papers (2018–2021)Ashley Turka · Bluebird Bio (United States)7 papers (2018–2020)Deepu Madduri · Johnson & Johnson (United States)7 papers (2018–2020)Jacalyn Rosenblatt · Harvard University6 papers (2018–2020)Monica Massaro · Boston Biomedical (United States)6 papers (2018–2019)Michaela Liedtke · Stanford University6 papers (2018–2025)Nina Shah · Kaiser Permanente5 papers (2018–2021) · 5 papers (2018–2019)Luciano J. Costa · Baylor University5 papers (2019–2025)Marcela V. Maus · Harvard University4 papers (2018–2019)James N. Kochenderfer · National Institutes of Health4 papers (2018–2019)Larry D. Anderson · Myeloma UK4 papers (2020–2023)
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