Area of research
Molecular Biology · Surgery
Research interest
in the field of cardiovascular medicine is the prospect of using stem cells and progenitor cells for cardiac regeneration. With the advent of induced pluripotent stem cell (iPSC) technology, major efforts are also underway to use iPSCs to model heart disease, to screen for new drugs, and to test candidate drugs for cardiotoxicity. Here, we discuss recent advances in the exciting fields of stem cells and cardiovascular disease. View details for DOI 10.1126/scitranslmed.3008921 View details for Web of Science ID 000337184200004 Human-induced pluripotent stem cell models of inherited cardiomyopathies. Current opinion in cardiology Karakikes, I., Termglinchan, V., Wu, J. C. 2014 ; 29 (3) : 214-219 Abstract This article provides an overview of the latest advances in in-vitro modeling of inherit
Deficiency of Smooth Muscle Adar1 Exacerbates Vascular Remodeling and Pulmonary Hypertension.
Generation of two induced pluripotent stem cell lines from patients carrying heterozygous PTEN mutations associated with PTEN Hamartoma Tumor Syndrome.
Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery.
Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying RBM20 mutations.
Generation of two induced pluripotent stem cell lines from female patients harboring MYH7 mutations with hypertrophic cardiomyopathy.
Generation and characterization of two human induced pluripotent stem cell lines from myotonic dystrophy type 1 patients.
New approach methodologies for drug discovery.
Generation of induced pluripotent stem cell lines from patients with Emery-Dreifuss muscular dystrophy.
Modeling heart rhythm using human engineered heart tissues.
NEREA: A versatile computer vision-based software for analyzing angiogenesis.
Reimagining human-centric drug development with new approach methodologies.
Profiling Immune-Independent Response to Immune Checkpoint Inhibitors on Stem Cell-Derived Cardiomyocytes, Organoids, and Mouse Models.
Artificial intelligence in drug development
Engineered heart muscle allografts for heart repair in primates and humans
Engineered heart muscle allografts for heart repair in primates and humans.
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization.
Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use
Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis.
The relationship between cannabis and cardiovascular disease: clearing the haze.
Opportunities and challenges for the use of human samples in translational cardiovascular research: a scientific statement of the ESC Working Group on Cellular Biology of the Heart, the ESC Working Group on Cardiovascular Surgery, the ESC Council on Basic Cardiovascular Science, the ESC Scientists of Tomorrow, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the Heart Failure Association of the ESC
In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome.
ADMET-AI Enables Interpretable Predictions of Drug-Induced Cardiotoxicity.
Achieving inclusive healthcare through integrating education and research with AI and personalized curricula
Lamin: guardian against DNA damage by transcription stress.
Olmesartan Restores <i>LMNA</i> Function in Haploinsufficient Cardiomyocytes.
Molecular Mechanisms of Exosomes From Human iPSC‐Cardiomyocytes and Mesenchymal Stem Cells in Restoring the Injured Myocardium
A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function
Generation of induced pluripotent stem cell lines from patients with thoracic aortic aneurysm carrying the ACTA2 gene mutation.
Principles for the Future of Biomedical Research in the United States and Optimizing the National Institutes of Health: A Presidential Advisory From the American Heart Association.