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Lei Tian

State Key Laboratory of Digital Medical Engineering · CN
Area of research
Molecular Biology · Oncology
Research interest
Research interests include Congenital heart defects research, RNA modifications and cancer, Single-cell and spatial transcriptomics, and Pluripotent Stem Cells Research.
h-index
43
citations
6,191
works
151
NIH funding
primary concept
Biology
email

Recent publications

Bioactive hydrogels for the reconstruction of sensorineural hearing loss
Bioactive Materials 2025cited by 2position: middledoi
MgFe-LDH-doped GelMA hydrogel scaffold repaired spinal cord injury via immunoregulation and enhancement of neuronal differentiation
Nano Today 2025cited by 1position: middledoi
Bioactive hydrogels loaded with BMSC-EXOs and GDNF for synergistically spinal cord injury repairing
Composites Part B Engineering 2024cited by 22position: middledoi
Analysis of sex-biased gene expression in a Eurasian admixed population
Briefings in Bioinformatics 2024cited by 6position: middledoi
Expression profiles of east–west highly differentiated genes in Uyghur genomes
National Science Review 2023cited by 23position: middledoi
Positive effect of carbohydrate-metabolizing bacteria determines increasing soil organic carbon during long-term fertilization and straw returning in the black soil region of China
Pedosphere 2023cited by 15position: middledoi
Abstract 9501: Single-Cell Transcriptomic Analysis and Patient-Specific iPSCs Reveal Dysfunctional Coronary Arterial Endothelial Cells in Hypoplastic Left Heart Syndrome
Circulation 2022cited by 0position: middledoi
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
Cancer Cell 2020cited by 232position: middledoi
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
Cell stem cell 2020cited by 228position: middledoi
Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome
Cell stem cell 2020cited by 168position: middledoi
Abstract 12937: Single-cell Transcriptomic Analysis Reveals Developmentally Impaired Endocardial Population in Hypoplastic Left Heart Syndrome
Circulation 2020cited by 2position: middledoi
Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Circulation 2019cited by 198position: middledoi
Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution
Circulation Research 2019cited by 189position: middledoi
Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell–Derived Endothelial Cells
Journal of the American College of Cardiology 2019cited by 159position: middledoi
A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles
Cell stem cell 2019cited by 134position: middledoi
Single cell expression analysis reveals anatomical and cell cycle-dependent transcriptional shifts during heart development
Development 2019cited by 83position: middledoi
Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders
National Science Review 2019cited by 76position: middledoi
S100A10 Is a Critical Mediator of GAS6/AXL–Induced Angiogenesis in Renal Cell Carcinoma
Cancer Research 2019cited by 60position: middledoi
Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development
Stem Cell Reports 2019cited by 60position: middledoi
Abstract 642: Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells
Circulation Research 2019cited by 5position: middledoi
ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation
Cellular Physiology and Biochemistry 2018cited by 294position: middledoi
Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells
Circulation Research 2018cited by 148position: middledoi
<i>UBD</i> modifies <i>APOL1</i> -induced kidney disease risk
Proceedings of the National Academy of Sciences 2018cited by 68position: middledoi
MultiWaver 2.0: modeling discrete and continuous gene flow to reconstruct complex population admixtures
European Journal of Human Genetics 2018cited by 47position: middledoi
Diverse <i>BRCA1</i> and <i>BRCA2</i> Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer
Clinical Cancer Research 2017cited by 256position: middledoi
Genetic History of Xinjiang’s Uyghurs Suggests Bronze Age Multiple-Way Contacts in Eurasia
Molecular Biology and Evolution 2017cited by 94position: middledoi
Higher-Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function
Molecular Cell 2015cited by 63position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Joseph C. Wu · Ningbo No.6 Hospital11 papers (2018–2022)Sean M. Wu · Cardiovascular Institute of the South7 papers (2018–2022)David T. Paik · Stanford University4 papers (2018–2019)Shuhua Xu · Fudan University4 papers (2017–2024)Yajun Yang · Fudan University3 papers (2017–2024)Dongsheng Lu · Guangxi Medical University3 papers (2017–2024) · 3 papers (2017–2024) · 3 papers (2020–2022)Hongchao Guo · University of Utah3 papers (2019–2019)Joe Z. Zhang · Cardiovascular Institute of the South3 papers (2019–2019)Tomoya Kitani · California Institute for Regenerative Medicine3 papers (2019–2019)Jan-Willem Buikema · Utrecht University3 papers (2018–2019)Nazish Sayed · Palo Alto University3 papers (2018–2019)Yangnan Hu · Nantong University3 papers (2024–2025)Marlene Rabinovitch · Lucile Packard Children's Hospital3 papers (2020–2022)Nan Ma · Jiangsu University of Science and Technology3 papers (2019–2020)Mingxia Gu · Community Health Center3 papers (2020–2022)Yifei Miao · Donghua University3 papers (2020–2022)Renjie Chai · Fudan University3 papers (2024–2025)Seema Mital · Sinai Health System3 papers (2020–2022)