Fengping Wu

Area of research

Rheumatology · Genetics

Research interest

Research topics from publications: B Cells in Rheumatoid Arthritis：Pathogenic Mechanisms and Treatment Prospects; Mesenchymal stem cells and their microenvironment; Knowledge Mapping of Exosomes in Autoimmune Diseases: A Bibliometric Analysis (2002–2021); Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects; Bibliometric and visualization analysis of mesenchymal stem cells and rheumatoid arthritis (from 2012 to 2021); High Follicle-Stimulating Hormone Level Associated With Risk of Rheumatoid Arthritis and Disease Activity. Representative work: Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its clinical features are the proliferation of joint synovial tissue, the formation of pannus and the destruction of cartilage. The global incidence of RA is about 1%, and it is more common in women. The basic feature of RA is the body’s immune system disorders, in which autoreactive CD4 + T cells, pathogenic B cells, M1 macrophages, inflammatory cytokines, chemokines and autoantibodies abnormally increase in the body of RA patients B cell depletion therapy has well proved the important role of B cells in the pathogenesis of RA, and the treatment of RA with B cells as a target has also been paid more and more at Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and humoral components. It is also the place for cells' interaction. The stability of the microenvironment is pivotal for maintaining cell proliferation, differentiation, metabolism and functional activities. Abnormal changes in microenvironment components can interfere cell functions. In some diseases, MSCs can interact with the microenvironment and accelerate disease progression. This review will discuss the