Area of research
Molecular Biology
Research interest
Research interests include Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Developmental Biology and Gene Regulation, and Congenital heart defects research.
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates
Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets.
Stable bioreactor control reveals acidic pH-driven metabolic reprogramming and mitochondrial dysfunction in human lymphoblastoid cells.
A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation.
Anti-aging strategies and ex vivo organ rejuvenation
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming.
Reactivation of retrotransposable elements is associated with environmental stress and ageing.
Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models.
Escaping ageing through Cell Annealing-a phenomenological model.
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging.
Complex regulatory networks influence pluripotent cell state transitions in human iPSCs
Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing.
In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin.
Universal DNA methylation age across mammalian tissues
Resurrection of endogenous retroviruses during aging reinforces senescence
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
DNA methylation networks underlying mammalian traits
m<sup>6</sup>A epitranscriptomic regulation of tissue homeostasis during primate aging.
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing.
eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk
Quantitative haplotype-resolved analysis of mitochondrial DNA heteroplasmy in Human single oocytes, blastoids, and pluripotent stem cells.
Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications.
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming
Author Correction: Universal DNA methylation age across mammalian tissues
Chemical fast track to induced pluripotency.
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