Area of research
Immunology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include T-cell and B-cell Immunology, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research, and CAR-T cell therapy research.
Cbl-b mitigates the responsiveness of naive CD8 <sup>+</sup> T cells that experience extensive tonic T cell receptor signaling
Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells
Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen
ZAP70, too little, too much can lead to autoimmunity*
Adapting T Cell Receptor Ligand Discrimination Capability via LAT
Cbl-b deficiency prevents functional but not phenotypic T cell anergy
Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway
Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
How the T cell signaling network processes information to discriminate between self and agonist ligands
CD45 functions as a signaling gatekeeper in T cells
Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination
Adaptation by naïve CD4 <sup>+</sup> T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance
Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization
CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation
Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148
TCR Signaling: Mechanisms of Initiation and Propagation
ZAP-70 in Signaling, Biology, and Disease
IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level
A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45
IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells