Area of research
Pharmacology · Molecular Biology
Research interest
Research interests include Pharmacogenetics and Drug Metabolism, Cancer therapeutics and mechanisms, Carcinogens and Genotoxicity Assessment, and Drug-Induced Hepatotoxicity and Protection.
Transformation of Mangiferin to Norathyriol by Human Fecal Matrix in Anaerobic Conditions: Comprehensive NMR of the Xanthone Metabolites, Antioxidant Capacity, and Comparative Cytotoxicity Against Cancer Cell Lines
Expression Patterns of Xenobiotic-Metabolizing Enzymes in Tumor and Adjacent Normal Mucosa Tissues among Patients with Colorectal Cancer: The ColoCare Study
The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells
Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches
Cytochrome b 5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems
The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[<i>a</i>]pyrene in human livers
NADH:Cytochrome <i>b</i><sub>5</sub> Reductase and Cytochrome <i>b</i><sub>5</sub> Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[<i>a</i>]pyrene
Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1
NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1
Induced expression of microsomal cytochrome b 5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I)
Correction to NADH:Cytochrome <i>b</i><sub>5</sub> Reductase and Cytochrome <i>b</i><sub>5</sub> Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[<i>a</i>]pyrene
Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[<i>a</i>]pyrene
Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells
Mycotoxin ochratoxin A decreases cytochrome P450-mediated detoxication of carcinogenic aristolochic acid thereby increases its genotoxic potential in rats in vivo
NADPH- and NADH-dependent formation of DNA adducts by benzo[a]pyrene catalyzed with cytochrome P450 1A1
Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare)
Cytochrome b and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions
Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches
The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes
The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats
The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats
The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats—A comparative study
Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study
Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats — A Comparative Study
Dicoumarol inhibits NAD(P)H:quinone oxidoreductase-mediated formation of aristolochic acid-DNA adducts in vitro whereas increases their generation in rats in vivo
Aryl hydrocarbon receptor ligands benzo[a]pyrene, ellipticine and Sudan I are potent inducers of cytochrome b5 in rats
The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat