Area of research
Pharmacology · Cancer Research
Research interest
Research interests include Carcinogens and Genotoxicity Assessment, Nephrotoxicity and Medicinal Plants, Drug-Induced Hepatotoxicity and Protection, and Pharmacogenetics and Drug Metabolism.
Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis
Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
Co-Exposure to Aristolochic Acids I and II Increases DNA Adduct Formation Responsible for Aristolochic Acid I-Mediated Carcinogenicity in Rats
Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts
A Compendium of Mutational Signatures of Environmental Agents
Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid
Co-exposure to polystyrene plastic beads and polycyclic aromatic hydrocarbon contaminants in fish gill (RTgill-W1) and intestinal (RTgutGC) epithelial cells derived from rainbow trout (Oncorhynchus mykiss)
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells
Determination of genomic N3‐methylthymidine in human cancer cells treated with nitrosamines using capillary electrophoresis with laser‐induced fluorescence
Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice
The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells
Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells
Erratum to “Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53” [Toxicol. Appl. Pharmacol. 232(1) (2008) 86–98]
DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer
Assessing the impact of Benzo[a]pyrene on Marine Mussels: Application of a novel targeted low density microarray complementing classical biomarker responses
Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene
Altered gene expression profiles in the lungs of benzo[ a ]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation
Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches
Cytochrome b 5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems
Balkan endemic nephropathy: an update on its aetiology
The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[<i>a</i>]pyrene in human livers
Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos
The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans
NADH:Cytochrome <i>b</i><sub>5</sub> Reductase and Cytochrome <i>b</i><sub>5</sub> Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[<i>a</i>]pyrene
Nutlin‐3a selects for cells harbouring <scp><i>TP</i></scp><i>53</i> mutations
Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo