Area of research
Cancer Research · Health, Toxicology and Mutagenesis
Research interest
Research interests include Carcinogens and Genotoxicity Assessment, Effects and risks of endocrine disrupting chemicals, Computational Drug Discovery Methods, and Animal testing and alternatives.
New approach methodologies in human regulatory toxicology – Not if, but how and when!
Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)
Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU
Determination of in vitro hepatotoxic potencies of a series of perfluoroalkyl substances (PFASs) based on gene expression changes in HepaRG liver cells
New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts
Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
DNA methylation trajectories and accelerated epigenetic aging in incident type 2 diabetes
Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach
A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences
New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs
Correction to: Toxicogenomics directory of chemically exposed human hepatocytes
Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide
Methodology for health risk assessment of combined exposures to multiple chemicals
Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts
A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals
Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene
Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution
Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts
TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts
Toxicogenomics directory of chemically exposed human hepatocytes
Slow accumulation of mutations in Xpc−/− mice upon induction of oxidative stress