Area of research
Molecular Biology · Immunology
Research interest
Research interests include Cell biology, Biology, P-TEFb, Innate immune system, IRF3, and Transcription (linguistics).
Targeting FOXM1 condensates reduces breast tumour growth and metastasis
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing
AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation
R-loop-dependent promoter-proximal termination ensures genome stability
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
A subcellular map of the human kinome
Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold