Area of research
Nephrology · Rheumatology
Research interest
Research topics from publications: Exploring macrophage heterogeneity in IgA nephropathy: Mechanisms of renal impairment and current therapeutic targets; Identification of Unique Genetic Biomarkers of Various Subtypes of Glomerulonephritis Using Machine Learning and Deep Learning; GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN; Dual Anti-Glomerular Basement Membrane and Anti-Neutrophil Cytoplasmic Antibodies—Positive Rapidly Progressive Glomerulonephritis with Rheumatoid Arthritis and Sjogren’s Syndrome: A Case Report and Literature Review. Representative work: The lack of understanding of the mechanism of renal injury in IgA nephropathy (IgAN) hinders the development of personalized treatment plans and targeted therapies. Improved insight into the cause of renal dysfunction in IgAN is necessary to enhance the effectiveness of strategies for slowing the progression of the disease. This study examined single cell RNA sequencing (scRNA seq) and bulk-RNA seq data and found that the gene expression of renal intrinsic cells (RIC) was significantly changed in patients with renal impairment, with a primary focus on energy metabolism. We discovered a clear metabolic reprogramming of RIC during renal function impairment (RF) using the ’scMetabolism’ package (1) Objective: Identification of potential genetic biomarkers for various glomerulonephritis (GN) subtypes and discovering the molecular mechanisms of GN. (2) Methods: four microarray datasets of GN were downloaded from Gene Expression Omnibus (GEO) database and merged to obtain the gene expression profiles of eight GN subtypes. Then, differentially expressed immune-related genes (DIRGs) were identified to explore the molecular mechanisms of GN, and single-sample gene set enrichment analysis (ssGSEA) was performed to discover the abnormal inflammation in GN. In addition, a nomogram model was generated using the R package "glmnet", and the calibration curve was plotted to evaluate the predict
GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN
Exploring macrophage heterogeneity in IgA nephropathy: Mechanisms of renal impairment and current therapeutic targets
Identification of Unique Genetic Biomarkers of Various Subtypes of Glomerulonephritis Using Machine Learning and Deep Learning
Dual Anti-Glomerular Basement Membrane and Anti-Neutrophil Cytoplasmic Antibodies—Positive Rapidly Progressive Glomerulonephritis with Rheumatoid Arthritis and Sjogren’s Syndrome: A Case Report and Literature Review