Area of research
Biophysics · Biomedical Engineering
Research interest
Research topics from publications: GPX4 expression changes in proximal tubule cells highlight the role of ferroptosis in IgAN. Representative work: As an important mechanism of renal injury, oxidative stress (OS) is inseparable from the occurrence of renal fibrosis and the rapid progression of renal failure. However, the contribution of OS to IgA nephropathy (IgAN), the primary driver of chronic kidney disease remains uncertain. To investigate the effects of OS in IgAN, and identify the mechanisms of cell and tissue injury and protection, single-cell RNA sequencing (scRNA-seq) data and microarray data of IgAN were collected and analyzed. Through gene set variation analysis (GSVA), we identified significant alterations in the activity of multiple OS pathways within the proximal tubule cells (PTCs) of IgAN patients. Subsequent enrichment