Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Single-cell and spatial transcriptomics, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, and Cancer Genomics and Diagnostics.
The Somatic Mosaicism across Human Tissues Network
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
Unified molecular approach for spatial epigenome, transcriptome, and cell lineages
Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation
Invigorating discovery and clinical translation of aging biomarkers
Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase
Deciphering the impact of genomic variation on function
Expansion <i>in situ</i> genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin repression
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors
A transcription factor atlas of directed differentiation
Heritable transcriptional defects from aberrations of nuclear architecture
Systematic benchmarking of single-cell ATAC-sequencing protocols
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens
Author Correction: Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung
DSpace@MIT (Massachusetts Institute of Technology) 2022cited by 86position: middle
Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
In situ genome sequencing resolves DNA sequence and structure in intact biological samples
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Single-cell ATAC-seq reveals GATA2-dependent priming defect in myeloid and a maturation bottleneck in lymphoid lineages
1508 Single-cell epigenetic profiling highlights genetic impact on chromatin accessibility in SLE
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma