Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Genomics and Chromatin Dynamics, Single-cell and spatial transcriptomics, RNA and protein synthesis mechanisms, and RNA Research and Splicing.
Three-dimensional genome landscape of primary human cancers
Spatial proteomics of Alzheimer’s disease-specific human microglial states
MorPhiC Consortium: towards functional characterization of all human genes
Thymic epithelial cells amplify epigenetic noise to promote immune tolerance
Compact RNA sensors for increasingly complex functions of multiple inputs
Enhancing transcription–replication conflict targets ecDNA-positive cancers
Massively parallel characterization of regulatory elements in the developing human cortex
Multicenter integrated analysis of noncoding CRISPRi screens
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers
PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape
The killifish germline regulates longevity and somatic repair in a sex-specific manner
Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders
Abstract B008: The polyclonal path towards malignant transformation in familial adenomatous polyposis
Abstract 3872: Multi-ancestral origins of colorectal lesionsMulti-ancestral origins of colorectal lesions
Beyond the exome: What’s next in diagnostic testing for Mendelian conditions
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases
Single-cell transcriptomic landscape of the developing human spinal cord
Systematic benchmarking of single-cell ATAC-sequencing protocols
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria
CasKAS: direct profiling of genome-wide dCas9 and Cas9 specificity using ssDNA mapping
The chromatin landscape of the euryarchaeon Haloferax volcanii
Single-cell chromatin state transitions during epigenetic memory formation
Abstract 3497: The polyclonal path to malignant transformation in familial adenomatous polyposis
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks
Engineered cell entry links receptor biology with single-cell genomics
High-throughput biochemical profiling reveals functional adaptation of a bacterial Argonaute
The chromatin organization of a chlorarachniophyte nucleomorph genome