Area of research
Molecular Biology · Rheumatology
Research interest
Research interests include CRISPR and Genetic Engineering, Porphyrin Metabolism and Disorders, Single-cell and spatial transcriptomics, and DNA Repair Mechanisms.
Comprehensive interrogation of synthetic lethality in the DNA damage response.
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.
Vaginal lactobacilli produce anti-inflammatory β-carboline compounds.
Dissecting host-microbe interactions with modern functional genomics.
Microfluidics-free single-cell genomics with templated emulsification
Microfluidics-free single-cell genomics with templated emulsification.
Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase
Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase.
Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Adaptive exchange sustains cullin-RING ubiquitin ligase networks and proper licensing of DNA replication.
High-content imaging-based pooled CRISPR screens in mammalian cells.
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
CRISPR-based functional genomics in human dendritic cells
CRISPR-based functional genomics in human dendritic cells.
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis
Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.
High-content imaging-based pooled CRISPR screens in mammalian cells
Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent