Area of research
Inorganic Chemistry · Renewable Energy, Sustainability and the Environment
Research interest
Research interests include Metal-Catalyzed Oxygenation Mechanisms, Metalloenzymes and iron-sulfur proteins, Porphyrin Metabolism and Disorders, and Enzyme Structure and Function.
A highly dynamic mononuclear non-heme iron enzyme for the two-step isonitrile biosynthesis
PexR is a noncanonical regulator of the peroxide stress response in bacteria
A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile
Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy
2.6-Å resolution cryo-EM structure of a class Ia ribonucleotide reductase trapped with mechanism-based inhibitor N <sub>3</sub> CDP
How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase
Potent Inhibition of <i>E. coli</i> DXP Synthase by a <i>gem</i>-Diaryl Bisubstrate Analog
Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway
Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase
Development of an in vitro method for activation of X-succinate synthases for fumarate hydroalkylation
Structural insight into G-protein chaperone-mediated maturation of a bacterial adenosylcobalamin-dependent mutase
A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria
Cobalamin-Dependent Radical <i>S</i>-Adenosylmethionine Enzymes: Capitalizing on Old Motifs for New Functions
Approaches to Using the Chameleon: Robust, Automated, Fast-Plunge cryoEM Specimen Preparation
Structural Insights into Microbial One-Carbon Metabolic Enzymes Ni–Fe–S-Dependent Carbon Monoxide Dehydrogenases and Acetyl-CoA Synthases
Visualizing the gas channel of a monofunctional carbon monoxide dehydrogenase
The role of nucleoside triphosphate hydrolase metallochaperones in making metalloenzymes
Starting a new chapter on class Ia ribonucleotide reductases
The Atypical Cobalamin-Dependent <i>S</i>-Adenosyl-<scp>l</scp>-Methionine Nonradical Methylase TsrM and Its Radical Counterparts
A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates
Characterization of an <i>S</i> ‐adenosylmethionine Dependent X‐Succinate Synthase Activating Enzyme
Repairing enzymes using spare parts
Cryo‐EM Structural Determination of Met18, a Scaffold Protein for Iron‐Sulfur Protein Maturation
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase
Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
Rescuing activity of oxygen-damaged pyruvate formate-lyase by a spare part protein
Crystal Structure of the [4Fe–4S] Cluster-Containing Adenosine-5′-phosphosulfate Reductase from <i>Mycobacterium tuberculosis</i>
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex