Area of research
Inorganic Chemistry · Oncology
Research interest
Research focused on Ribonucleotide reductase and Ribonucleotide, with related work in Cofactor, Polyhydroxybutyrate, Escherichia coli. Notable publications include 'Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase', 'Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets', and 'Mechanism of Assembly of the Dimanganese-Tyrosyl Radical Cofactor of Class Ib Ribonucleotide Reductase: Enzymatic Generation of Superoxide Is Required for Tyrosine Oxidation via a...'.
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
Basis of dATP inhibition of RNRs
Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer
Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator
Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: <i>E. coli</i> Ribonucleotide Reductase As an Example
Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer
Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway of<i>E. coli</i>α2 Ribonucleotide Reductase
Choosing the Right Metal: Case Studies of Class I Ribonucleotide Reductases
The class III ribonucleotide reductase from <i>Neisseria bacilliformis</i> can utilize thioredoxin as a reductant
Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase
Mechanism of Assembly of the Dimanganese-Tyrosyl Radical Cofactor of Class Ib Ribonucleotide Reductase: Enzymatic Generation of Superoxide Is Required for Tyrosine Oxidation via a Mn(III)Mn(IV) Intermediate
Function of the Diiron Cluster of<i>Escherichia coli</i>Class Ia Ribonucleotide Reductase in Proton-Coupled Electron Transfer
Generation of a stable, aminotyrosyl radical-induced α2β2 complex of <i>Escherichia coli</i> class Ia ribonucleotide reductase
Christian Raetz: Scientist and Friend Extraordinaire
Mechanistic Studies of Semicarbazone Triapine Targeting Human Ribonucleotide Reductase in Vitro and in Mammalian Cells
Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase
Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers