Area of research
Molecular Biology · Inorganic Chemistry
Research interest
Research interests include RNA and protein synthesis mechanisms, Genomics and Chromatin Dynamics, RNA Research and Splicing, and Metal-Catalyzed Oxygenation Mechanisms.
Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection
Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound
Mediator structure and rearrangements required for holoenzyme formation
Structure of an RNA polymerase II preinitiation complex
Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer
Structure of a designed protein cage that self-assembles into a highly porous cube
Structure and Flexibility of Nanoscale Protein Cages Designed by Symmetric Self-Assembly
Generation of a stable, aminotyrosyl radical-induced α2β2 complex of <i>Escherichia coli</i> class Ia ribonucleotide reductase
Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase
Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers