Area of research
Cell Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Molecular cell bioengineering is the application of engineering approaches to develop quantitative understanding of cell function in terms of fundamental molecular properties, and to apply this understanding for improved design of molecular- and cell-based technologies. The Lauffenburger research group focuses on elucidating important aspects of receptor-mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death.
Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
A practical guide to FAIR data management in the age of multi-OMICS and AI
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype
Age and sex influence antibody profiles associated with tuberculosis progression
Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques
Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth
Inference of drug off-target effects on cellular signaling using interactome-based deep learning
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling
Host genetic background is a barrier to broadly effective vaccine–mediated protection against tuberculosis
Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19
Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
Differences in HPV-specific antibody Fc-effector functions following Gardasil® and Cervarix® vaccination
Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates
Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions
Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains
Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection
Antibody effector functions are associated with protection from respiratory syncytial virus
Artificial neural networks enable genome-scale simulations of intracellular signaling
Selective transfer of maternal antibodies in preterm and fullterm children
Serological Markers of SARS-CoV-2 Reinfection
Collateral responses to classical cytotoxic chemotherapies are heterogeneous and sensitivities are sparse
An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19
Humoral signatures of protective and pathological SARS-CoV-2 infection in children
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
I-Corps L to discover a sustainable model that will support and scale BioBuilder's curriculum and teacher professional development activities
Engineering Growth Factor/Receptor Processes
MRI: Development of the MIT QMIP Network
EGF Receptor-Mediated DNA Uptake and Expression: A Model System for Engineering Selective Gene Delivery
Engineering Growth Factor/Receptor Processes
Engineering Growth Factor/Receptor Processes
Engineering Growth Factor/Receptor Processes
"Quantitative Studies of Binding and Trafficking of Endogenous and Genetically-Altered Epidermal Growth Factor Receptors in Cultured Fibroblasts."
Receptor-Mediated Cell Separations
Quantitative Studies of Bacterial Chemotaxis: Relationship to Cell Growth Optimization and Metabolic Preferences
Presidential Young Investigator Award: Influence of Chemical Stimulation on Bacterial Movement
Quantitative Studies of Bacterial Motility and Chemotaxis
Research Initiation - Motility and Cell Population Dynamics