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Linda G. Griffith

Massachusetts Institute of Technology · US
Area of research
Biomedical Engineering · Hepatology
Research interest
Research interests include 3D Printing in Biomedical Research, Liver physiology and pathology, Cancer Cells and Metastasis, and Cellular Mechanics and Interactions.
h-index
87
citations
29,423
works
408
NIH funding
primary concept
email

Recent publications

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
ALTEX 2025cited by 16position: middledoi
System- and sample-agnostic isotropic three-dimensional microscopy by weakly physics-informed, domain-shift-resistant axial deblurring
Nature Communications 2025cited by 9position: middledoi
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis
Molecular Human Reproduction 2025cited by 8position: middledoi
Deep and Dynamic Metabolic and Structural Imaging in Living Tissues
2025cited by 0position: middledoi
Deep and Isotropic Structural and Metabolic Imaging for Nucleolar Dynamics in Living Biosystems
2025cited by 0position: middledoi
A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis
Journal of Minimally Invasive Gynecology 2024cited by 35position: middledoi
An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii
npj Biofilms and Microbiomes 2024cited by 25position: lastdoi
Deep and dynamic metabolic and structural imaging in living tissues
Science Advances 2024cited by 12position: middledoi
Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk
Med 2023cited by 97position: lastdoi
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
Nature Communications 2022cited by 46position: middledoi
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
Cell stem cell 2022cited by 31position: middledoi
ENDOCELL-Seud: a Delphi protocol to harmonise methods in endometrial cell culturing
Reproduction and Fertility 2022cited by 2position: middledoi
A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids
Nature Materials 2021cited by 186position: middledoi
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
Science Advances 2021cited by 163position: lastdoi
Coculture of primary human colon monolayer with human gut bacteria
Nature Protocols 2021cited by 68position: lastdoi
Menstruation: science and society
American Journal of Obstetrics and Gynecology 2020cited by 426position: lastdoi
Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids
Cell Systems 2020cited by 214position: lastdoi
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids
Biomaterials 2020cited by 167position: lastdoi
Primary Human Colonic Mucosal Barrier Crosstalk with Super Oxygen-Sensitive Faecalibacterium prausnitzii in Continuous Culture
Med 2020cited by 125position: lastdoi
Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron
Nature Biotechnology 2020cited by 124position: middledoi
Engineering PEG-based hydrogels to foster efficient endothelial network formation in free-swelling and confined microenvironments
Biomaterials 2020cited by 94position: lastdoi
The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study
Reproductive Sciences 2020cited by 92position: middledoi
OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks
Scientific Reports 2019cited by 132position: lastdoi
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
Scientific Reports 2018cited by 466position: lastdoi
Perspective: The promise of multi-cellular engineered living systems
APL Bioengineering 2018cited by 162position: middledoi
Folding artificial mucosa with cell-laden hydrogels guided by mechanics models
Proceedings of the National Academy of Sciences 2018cited by 80position: middledoi
A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures
Molecular & Cellular Proteomics 2018cited by 55position: middledoi
Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing
Lab on a Chip 2018cited by 33position: middledoi
Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis
Journal of Biological Chemistry 2018cited by 23position: middledoi
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies
The AAPS Journal 2017cited by 216position: middledoi

Grants

REU Site: Biological Engineering Research Experience for Undergraduates - BE REU
NSF1005055$298,6882010–2013PIRePORTER
REU Site: Biological Engineering Research Experience for Undergraduates - BE REU
NSF0649152$283,5102007–2011PIRePORTER
Biotechnology Process Engineering Research Center
NSF9843342$15,945,4071998–2006PIRePORTER
Rural Middle Grades Mathematics Capacity-Building Standards-Based Curriculum Planning Project for West Central Arkansas Schools
NSF9814221$49,6621998–1999PIRePORTER
Development of a Minimal Synthetic Extracellular Matrix Which Stimulates Cell Migration (Collaborative Research)
NSF9632714$337,7051996–2000PIRePORTER
Presidential Young Investigator Award: Cell Interactions with Biomaterials
NSF9157321$312,5001991–1998PIRePORTER

Frequent collaborators

Douglas A. Lauffenburger · Ragon Institute of MGH, MIT and Harvard15 papers (2012–2021)David L. Trumper · Massachusetts Institute of Technology8 papers (2016–2024)Murat Cirit · Massachusetts Institute of Technology7 papers (2015–2017)Keith Isaacson · Massachusetts Institute of Technology7 papers (2012–2025)Alan Wells · UPMC Hillman Cancer Center7 papers (2014–2018)Donna B. Stolz · University of Pittsburgh Medical Center7 papers (2014–2018)Amanda M. Clark · University of Kentucky6 papers (2014–2018)Paula T. Hammond · Broad Institute6 papers (2012–2020)Steven R. Tannenbaum · Massachusetts Institute of Technology6 papers (2014–2018)David Hughes · Massachusetts Institute of Technology6 papers (2014–2017)Victor Hernandez‐Gordillo · Massachusetts Institute of Technology6 papers (2019–2024)Rebecca L. Carrier · Northeastern University5 papers (2015–2021)Raman Venkataramanan · University of Pittsburgh5 papers (2014–2018)Carissa L. Young · Massachusetts Institute of Technology5 papers (2014–2018)Charles Wright · Massachusetts Institute of Technology5 papers (2020–2024)Roger D. Kamm · Massachusetts Institute of Technology5 papers (2014–2025)Kirsten Schneider · Massachusetts Institute of Technology5 papers (2020–2024)Cynthia L. Stokes · Massachusetts Institute of Technology5 papers (2016–2017)Sarah Wheeler · University of Pittsburgh5 papers (2014–2018)Jeremy J. Velazquez · Massachusetts Institute of Technology4 papers (2014–2017)