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Jeff Holst

UNSW Sydney · AU
Area of research
Cancer Research · Biochemistry
Research interest
Research interests include Cancer, Hypoxia, and Metabolism, Amino Acid Enzymes and Metabolism, Epigenetics and DNA Methylation, and Cancer, Lipids, and Metabolism.
h-index
44
citations
8,166
works
235
NIH funding
primary concept
email

Recent publications

Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
Advanced Science 2024cited by 23position: middledoi
Inhibition of mitochondrial bioenergetics and hypoxia to radiosensitize diffuse intrinsic pontine glioma
Neuro-Oncology 2024cited by 11position: middledoi
Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
2023cited by 0position: middledoi
Data from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
2023cited by 0position: middledoi
Glutamine addiction promotes glucose oxidation in triple-negative breast cancer
Oncogene 2022cited by 54position: lastdoi
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
Clinical Cancer Research 2022cited by 22position: middledoi
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
eLife 2020cited by 199position: middledoi
Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer
Neurochemical Research 2020cited by 67position: middledoi
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
Cancer Cell 2019cited by 1,023position: middledoi
Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells
Journal of Biological Chemistry 2019cited by 97position: middledoi
Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer
Molecular Cancer Research 2019cited by 87position: middledoi
Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K <i>BRAF</i> -Mutant Melanoma
Clinical Cancer Research 2019cited by 73position: middledoi
RAB27A promotes melanoma cell invasion and metastasis <i>via</i> regulation of pro‐invasive exosomes
International Journal of Cancer 2018cited by 98position: middledoi
Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways
BMC Cancer 2018cited by 63position: lastdoi
SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation
Proceedings of the National Academy of Sciences 2018cited by 28position: middledoi
Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
Cancer & Metabolism 2017cited by 413position: middledoi
Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Nature Communications 2017cited by 111position: middledoi
ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma
Oncogenesis 2017cited by 79position: lastdoi
Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell–Mediated Immunotherapy
Cancer Research 2017cited by 61position: middledoi
Heritable expansion of the genetic code in mouse and zebrafish
Cell Research 2016cited by 71position: middledoi
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
Oncogene 2015cited by 583position: lastdoi
Targeting <scp>ASCT2</scp>‐mediated glutamine uptake blocks prostate cancer growth and tumour development
The Journal of Pathology 2015cited by 328position: lastdoi
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.
PubMed 2015cited by 276position: last
p27Kip1 signaling: Transcriptional and post-translational regulation
The International Journal of Biochemistry & Cell Biology 2015cited by 97position: middledoi
Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome
Oncotarget 2015cited by 89position: middledoi
Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening
PLoS Computational Biology 2015cited by 69position: middledoi
Targeting glutamine transport to suppress melanoma cell growth
International Journal of Cancer 2014cited by 218position: lastdoi
Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
Cell 2013cited by 496position: middledoi
The cancer‐testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells
International Journal of Cancer 2013cited by 51position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Michelle van Geldermalsen · The University of Sydney11 papers (2014–2022)Qian Wang · Xi'an Honghui Hospital9 papers (2013–2022)Angel Pang · UNSW Sydney7 papers (2017–2023)John E.J. Rasko · The University of Sydney7 papers (2013–2017)Andrew J. Hoy · The University of Sydney5 papers (2015–2022)Charles G. Bailey · The University of Sydney5 papers (2013–2015)Lisa M. Butler · South Australian Research and Development Institute5 papers (2019–2023)Yi Fang Guan · Wuhan University5 papers (2018–2023)Seher Balaban · The University of Sydney4 papers (2015–2022)Rajini Nagarajah · The University of Sydney4 papers (2015–2017)Annora Thoeng · National Hospital for Neurology and Neurosurgery4 papers (2013–2017)Dadi Gao · Harvard University4 papers (2013–2017) · 4 papers (2020–2023)Nicholas Otte · Centenary Institute4 papers (2014–2017)Natalia Pinello · The University of Sydney3 papers (2013–2017)Christopher McNair · Thomas Jefferson University3 papers (2022–2023)Mark Schreuder · Leiden University Medical Center3 papers (2015–2019)Renae M. Ryan · The University of Sydney3 papers (2014–2020)Leonard G. Gomella · Thomas Jefferson University3 papers (2022–2023)Matthew J. Schiewer · Thomas Jefferson University3 papers (2022–2023)