Area of research
Molecular Biology · Neurology
Research interest
Research interests include RNA Research and Splicing, Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, and RNA modifications and cancer.
Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation
METTL14 is a chromatin regulator independent of its RNA <i>N</i> <i>6</i>-methyladenosine methyltransferase activity
Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration
Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Exploring the brain epitranscriptome: perspectives from the NSAS summit
Cell-specific regulation of gene expression using splicing-dependent frameshifting
Cell-specific regulation of gene expression using splicing-dependent frameshifting
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism
Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration