Area of research
Molecular Biology · Neurology
Research interest
Research interests include Cell death mechanisms and regulation, Amyotrophic Lateral Sclerosis Research, Autophagy in Disease and Therapy, and Neurogenetic and Muscular Disorders Research.
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS