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Edward B. Lee

University of California, Davis · US
Area of research
Neurology · Physiology
Research interest
Research interests include Alzheimer's disease research and treatments, Parkinson's Disease Mechanisms and Treatments, Dementia and Cognitive Impairment Research, and Amyotrophic Lateral Sclerosis Research.
h-index
78
citations
27,245
works
430
NIH funding
primary concept
Medicine
email

Recent publications

Single-Nuclei Transcriptomic Characterization of <i>APOE4</i> -Associated Alzheimer’s Disease
bioRxiv (Cold Spring Harbor Laboratory) 2026cited by 0position: middledoi
Resolving tissue complexity by multimodal spatial omics modeling with MISO
Nature Methods 2025cited by 51position: middledoi
Comparison of plasma p‐tau217/Aβ42, p‐tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease
Alzheimer s & Dementia 2025cited by 19position: middledoi
TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience 2025cited by 16position: middledoi
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Nature Communications 2025cited by 13position: middledoi
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron 2025cited by 8position: middledoi
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Brain 2025cited by 6position: middledoi
Copy Number Variation and Haplotype Analysis of <scp>17q21.31</scp> Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells
Movement Disorders 2025cited by 1position: middledoi
Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 0position: middledoi
Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology
Nature Biotechnology 2024cited by 172position: middledoi
A cross‐sectional study of α‐synuclein seed amplification assay in Alzheimer's disease neuroimaging initiative: Prevalence and associations with Alzheimer's disease biomarkers and cognitive function
Alzheimer s & Dementia 2024cited by 74position: middledoi
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
Cell 2024cited by 67position: middledoi
Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity
Alzheimer s & Dementia 2024cited by 42position: middledoi
Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics
Cell 2024cited by 38position: middledoi
Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid
Alzheimer s & Dementia 2024cited by 37position: middledoi
Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials
Alzheimer s & Dementia 2024cited by 33position: middledoi
Alzheimer’s disease seeded tau forms paired helical filaments yet lacks seeding potential
Journal of Biological Chemistry 2024cited by 26position: middledoi
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Molecular Neurodegeneration 2024cited by 25position: middledoi
Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations
Alzheimer s & Dementia 2024cited by 24position: middledoi
MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
The Lancet Neurology 2024cited by 23position: middledoi
ADNI Biomarker Core: A review of progress since 2004 and future challenges
Alzheimer s & Dementia 2024cited by 21position: middledoi
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology
Movement Disorders 2024cited by 17position: middledoi
Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease
Molecular Neurodegeneration 2024cited by 17position: middledoi
The ADNI4 Digital Study: A novel approach to recruitment, screening, and assessment of participants for AD clinical research
Alzheimer s & Dementia 2024cited by 15position: middledoi
Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment
Brain 2024cited by 15position: middledoi
Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
Hippocampus 2024cited by 14position: middledoi
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature 2024cited by 4position: middledoi
Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Molecular Neurodegeneration 2024cited by 2position: middledoi
Epigenetic signatures of regional tau pathology and cognition in the aging and pathological brain
medRxiv 2024cited by 1position: middledoi
Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and <i>MAPT</i> Sub-haplotypes
medRxiv 2024cited by 0position: middledoi

Grants

CPS: TTP Option: Small: Consistency vs. Availability in Cyber-Physical Systems
NSF2233769$599,0002023–2025PIRePORTER
CPS: Small: Reconciling Safety with the Internet for Cyber-Physical Systems
NSF1836601$499,0372018–2021PIRePORTER
CPS: Breakthrough: A Mathematical Theory of Cyber-Physical Systems
NSF1446619$499,3002015–2018PIRePORTER
CPS: Medium: Timing-Centric Software
NSF1035672$790,0002010–2014PIRePORTER
Collaborative Research: CSR-EHS: Pret: Precision Timed Architectures
NSF0720882$819,0722007–2013PIRePORTER
CSR-CPS: Action Webs Seedling
NSF0720841$129,9982007–2009PIRePORTER
CSR-SGER: Cyber-Physical Systems - Are Computing Foundations Adequate?
NSF0647591$150,0002006–2008PIRePORTER
SUPERB (Summer Undergraduate Progam in Engineering Research at Berkeley)
NSF0453604$200,9102005–2009PIRePORTER
CAREER: Field-Programmable Mixed Analog and Digital Array
NSF9702473$200,0001997–2002PIRePORTER
Design Methodology for Signal Processing
NSF9201605$231,2211992–1995PIRePORTER
Prototype Learning Laboratory Extension
NSF8751111$480,5401988–1990PIRePORTER
PYI: Communications, Signal Processing Applications of Computer Software & Hardware
NSF8657523$316,0001987–1992PIRePORTER
Formation, Detection and Characterization of Reaction Inter-mediates of Atmospheric Interest
NSF8316572$189,1001984–1987PIRePORTER
Electronically Excited Molecules (Chemistry)
NSF8217121$299,0261983–1986PIRePORTER
International Conference on Radiationless Transitions (Chemistry)
NSF8320664$3,5001983–1984PIRePORTER
Electronically Excited Molecules
NSF7925451$254,4001980–1983PIRePORTER
Luminescence and Kinetics of Electronically Excited Molecules
NSF7680383$144,4001977–1980PIRePORTER
Electronically Excited Molecules
NSF7400707$93,4001974–1977PIRePORTER

Frequent collaborators

John Q. Trojanowski · University of Pennsylvania12 papers (2013–2024)David J. Irwin · University of Pennsylvania9 papers (2013–2025)Virginia M.‐Y. Lee · Behavioral Health Services7 papers (2013–2024)Murray Grossman · University of Pennsylvania7 papers (2013–2023)Corey T. McMillan · University of Pennsylvania5 papers (2015–2023)Vivianna M. Van Deerlin · Institute on Aging5 papers (2013–2019)David A. Wolk · Los Angeles Biomedical Research Institute5 papers (2013–2025)Sharon X. Xie · University of Pennsylvania5 papers (2013–2020)John Robinson · University of Wolverhampton5 papers (2013–2024)Jon B. Toledo · Houston Methodist4 papers (2013–2021)Gábor G. Kovács · University Health Network4 papers (2020–2022)Jian Hu · Lishui Vocational and Technical College4 papers (2021–2024)William W. Seeley · Hammersmith Hospital3 papers (2015–2024)Lauren Elman · Valve (United States)3 papers (2013–2023) · 3 papers (2024–2025)Leslie M. Shaw · Siemens (United States)3 papers (2024–2024)Ozioma C. Okonkwo · Alzheimer's Association3 papers (2024–2025)Michael W. Weiner · Hôpital Beau-Séjour3 papers (2024–2025)Mingyao Li · Guangdong Testing Institute for Product Quality Supervision3 papers (2021–2024)Lea T. Grinberg · Mayo Clinic in Arizona3 papers (2021–2024)