Area of research
Molecular Biology
Research interest
Research interests include Biology, Chromatin, Transcription factor, Hox gene, Computational biology, and CTCF.
CTCF-RNA interactions orchestrate cell-specific chromatin loop organization
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
Essential transcription factors for induced neuron differentiation
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
Capybara: A computational tool to measure cell identity and fate transitions
Synthetic regulatory reconstitution reveals principles of mammalian <i>Hox</i> cluster regulation
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
<i>De novo</i> assembly and delivery to mouse cells of a 101 kb functional human gene
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding
Differential abilities to engage inaccessible chromatin diversify vertebrate HOX binding patterns
Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes
Cell Reprogramming: The Many Roads to Success
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
cAMPr: A single-wavelength fluorescent sensor for cyclic AMP
RNA localization is a key determinant of neurite-enriched proteome
Deconvolving sequence features that discriminate between overlapping regulatory annotations
CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells
CTCF establishes discrete functional chromatin domains at the <i>Hox</i> clusters during differentiation
An Integrated Model of Multiple-Condition ChIP-Seq Data Reveals Predeterminants of Cdx2 Binding
Evolving Hox Activity Profiles Govern Diversity in Locomotor Systems
Mapping Neuronal Diversity One Cell at a Time
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